PyCon 2006 will be held in Dallas, TX at the end of February (Feb. 24-26). See http://us.pycon.org for more information.
Keynote speakers include Guido van Rossum on the state of Python development, Alan Runyan and Alexander Limi on Plone, and an interview with Bram Cohen, creator of BitTorrent. You can even suggest questions for Mr. Cohen!
Early-bird registration ends this Sunday, after which the cost increases by $65, so register as soon as you can.
The conference is followed by four days of development sprints on packages such as Zope, Django, Docutils, PyPy, and CPython. Sprints are free, and you can book a hotel room at the conference rate even if you're only attending the sprints.